Veterinary Prescription Drug Pet Medications
[Veterinary Drug Name]
Generic Name: Compound Niclosamide Tablets
[Composition] Niclosamide, Levamisole Hydrochloride
[Character] Light yellow tablet.
[Pharmacological Action]
Niclosamide is an anthelmintic for tapeworms. It is effective against Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus, and Hymenolepis in dogs, but less effective against Echinococcus multilocularis. Its mechanism of action is inhibiting the tapeworm’s glucose absorption and uncoupling oxidative phosphorylation in the mitochondria, blocking the tricarboxylic acid cycle, leading to lactate accumulation, which kills the tapeworm. Niclosamide is poorly absorbed from the gastrointestinal tract, maintaining high concentrations in the intestines. A small amount is absorbed and metabolized into inactive aminochloronitrofurazone metabolites, which are excreted mainly through the feces.
Levamisole hydrochloride is active against most nematodes in dogs. Its mechanism is stimulating the parasympathetic and sympathetic ganglia of the worms, with overall nicotine-like effects. At high concentrations, levamisole disrupts the nematodes’ glucose metabolism by blocking fumarate reductase and succinate oxidation, causing paralysis of the worms, and expelling live worms from the body.
[Indications]
Anthelmintic. Used to deworm tapeworms and roundworms in dogs.
[Dosage and Administration]
Based on niclosamide content:
Oral administration: 100 mg per kg body weight for each dose. Administer on an empty stomach or with a small amount of food. Alternatively, follow the veterinarian's instructions.
[Adverse Reactions]
Dogs may experience gastrointestinal disturbances, such as vomiting or diarrhea.
[Precautions]
Dogs are relatively sensitive to this product; do not overdose.
[Withdrawal Period]
No withdrawal period required.
[Specifications]
210 mg (Niclosamide 200 mg + Levamisole Hydrochloride 10 mg);
525 mg (Niclosamide 500 mg + Levamisole Hydrochloride 25 mg)
[Packaging]
7 tablets/strip x 1 strip/box
[Storage]
Store in a sealed container in a cool, dark place.
[Shelf Life]
2 years.
[Manufacturer]
Qingdao KDN Animal Pharmaceutical Co., Ltd.
Manufacturing Address: No. 85 Keyun Road, High-Tech Zone, Qingdao
Postal Code: 266000
Tel: 0532-87905398
Fax: 0532-87905229
